stability analysis of a model of atherogenesis an energy estimate approach模型的稳定性分析动脉粥样化形成一个能量估计方法.pdf

Computational and Mathematical Methods in Medicine Vol. 9, No. 2, June 2008, 121–142 Stability analysis of a model of atherogenesis: An energy estimate approach a b c d A.I. Ibragimov , C.J. McNeal , L.R. Ritter * and J.R. Walton aDepartment of Mathematics, Texas Tech University, Lubbock, TX 79409, USA; bDivision of Cardiology and Department of Pediatrics, Division of Endocrinology, Department of Internal Medicine, Scott and White, Temple, TX 76508, USA; cDepartment of Mathematics, Southern Polytechnic State University, Marietta, GA 30060, USA; dDepartment of Mathematics, Texas A M University, College Station, TX 77843-3368, USA ( Received 29 August 2007; final version received 12 December 2007 ) Atherosclerosis is a disease of the vasculature that is characterized by chronic inflammation and the accumulation of lipids and apoptotic cells in the walls of large arteries. This disease results in plaque growth in an infected artery typically leading to occlusion of the artery. Atherosclerosis is the leading cause of human mortality in the US, much of Europe, and parts of Asia. In a previous work, we introduced a mathematical model of the biochemical aspects of the disease, in particular the inflammatory response of macrophages in the presence of chemoattractants and modified low density lipoproteins. Herein, we consider the onset of a lesion as resulting from an instability in an equilibrium configuration of cells and chemical species. We derive an appropriate norm by taking an energy estimate approach and present stability criteria. A bio-physical analysis of the mathematical results is presented