stability analysis of a model of atherogenesis an energy estimate approach ii模型的稳定性分析动脉粥样化形成一个能量估计方法二.pdf

Computational and Mathematical Methods in Medicine Vol. 11, No. 1, March 2010, 67–88 Stability analysis of a model of atherogenesis: an energy estimate approach II a bc d e A.I. Ibragimov , C.J. McNeal , L.R. Ritter * and J.R. Walton aDepartment of Mathematics, Texas Tech University, Lubbock, TX 79409, USA; bDivision of Cardiology, Department of Internal Medicine, Temple, TX 76508, USA; cDivision of Endocrinology, Department of Pediatrics, Scott White, Temple, TX 76508, USA; dDepartment of Mathematics, Southern Polytechnic State University, Marietta, GA 30060, USA; eDepartment of Mathematics, Texas A M University, College Station, TX 77843-3368, USA (Received 21 July 2008; final version received 12 December 2008) This paper considers modelling atherogenesis, the initiation of atherosclerosis, as an inflammatory instability. Motivated by the disease paradigm articulated by Russell Ross, atherogenesis is viewed as an inflammatory spiral with positive feedback loop involving key cellular and chemical species interacting and reacting within the intimal layer of muscular arteries. The inflammation is modelled through a system of non- linear reaction–diffusion–convection partial differential equations. The inflammatory spiral is initiated as an instability from a healthy state which is defined to be an equilibrium state devoid of certain key inflammatory markers. Disease initiation is studied through a linear, asymptotic stability analysis of a healthy equilibrium state. Various theorems are proved giving conditions on system parameters guaranteeing stability of the health state and conditions on system par