diabetes, tzds, and bone a review of the clinical evidence糖尿病、服用tzd和骨临床证据的审查.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2006, Article ID 24502, Pages 1–6 DOI 10.1155/PPAR/2006/24502 Review Article Diabetes, TZDs, and Bone: A Review of the Clinical Evidence Ann V. Schwartz Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry Street, Suite 5700, San Francisco, CA 94107, USA Received 1 April 2006; Revised 7 July 2006; Accepted 10 July 2006 Evidence from rodent and in vitro models suggests that activation of PPAR-γ by thiazolidinediones (TZDs) causes increa