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Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2006, Article ID 31825, Pages 1– 11 DOI 10.1155/JBB/2006/31825 Review Article Dysregulation of Protein Phosphorylation/Dephosphorylation in Alzheimer’s Disease: A Therapeutic Target Cheng-Xin Gong, Fei Liu, Inge Grundke-Iqbal, and Khalid Iqbal Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314-6399, USA Received 8 November 2005; Revised 12 December 2005; Accepted 3