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Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2006, Article ID 45716, Pages 1–7 DOI 10.1155/JBB/2006/45716 Review Article Generation of RNAi Libraries for High-Throughput Screens Julie Clark and Sheng Ding Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA Received 12 February 2006; Accepted 3 April 2006 The completion of the genome sequencing for several organisms has created a great demand