genetic manipulations of ppars effects on obesity and metabolic disease遗传操作的ppars对肥胖和代谢疾病的影响.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2007, Article ID 12781, 12 pages doi:10.1155/2007/12781 Review Article Genetic Manipulations of PPARs: Effects on Obesity and Metabolic Disease Yaacov Barak and Suyeon Kim The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA Received 7 August 2006; Revised 10 November 2006; Accepted 16 November 2006 Recommended by Wallace Harrington The interest in genetic manipulations of PPARs is as old as their discovery as receptors of ligands with beneficial clinical activitie