helical conformation of the ad1 peptide in the aml1-eto–e-protein complexad1肽的螺旋构象aml1-eto-e-protein复杂.pdfVIP

Spectroscopy 23 (2009) 123–129 123 DOI 10.3233/SPE-2009-0390 IOS Press Helical conformation of the AD1 peptide in the AML1-ETO–E-protein complex Horea Porumb ∗ Université Paris 13, Bobigny, France and LBPA, UMR CNRS 8113, ENS de Cachan, Cachan, France Abstract. The AML1-ETO fusion protein is responsible for 15% of the acute myeloid leukaemias due to its interference with transcription activation by E-proteins. The eTAFH region of the AML1-ETO competes for the AD1 domain of E-prot