a brain-computer interface based on bilateral transcranial doppler ultrasound脑机接口基于双边经颅多普勒超声.pdfVIP

A Brain-Computer Interface Based on Bilateral Transcranial Doppler Ultrasound 1,2 1 ´ 1,3 4,5,6 1,2 Andrew J. B. Myrden *, Azadeh Kushki , Ervin Sejdic , Anne-Marie Guerguerian , Tom Chau 1 Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada, 2 Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada, 3 Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 4 Departments of Critical Care Medicine and Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada, 5 Neuroscience and Mental Health Research Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada, 6 Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Abstract In this study, we investigate the feasibility of a BCI based on transcranial Doppler ultrasound (TCD), a medical imaging technique used to monitor cerebral blood flow velocity. We classified the cerebral blood flow velocity changes associated with two mental tasks - a word generation task, and a mental rotation task. Cerebral blood flow velocity was measured simultaneously within the left and right middle cerebral arteries while nine able-bodied adults alternated between mental activity (i.e. word generation or mental rotation) and relaxation. Using linear discriminant analysis and a set of time-domain features, word generation and mental rotation were classified with respective average accuracies of 82.9% +10.5 and 85.7% +10.0 across all participants. Accuracies for all participants significantly exceeded chance. These results indicate t