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a comparative study of drosophila and human a-type lamins果蝇和人类a类型核纤层蛋白的比较研究
A Comparative Study of Drosophila and Human A-Type
Lamins
1 2 3 2 2
Sandra R. Schulze , Beatrice Curio-Penny , Sean Speese , George Dialynas , Diane E. Cryderman ,
2 2 1 3 2
Caitrin W. McDonough , Demet Nalbant , Melissa Petersen , Vivian Budnik , Pamela K. Geyer , Lori L.
Wallrath2*
1 Department of Biology, Western Washington University, Bellingham, Washington, United States of America, 2 Department of Biochemistry, University of Iowa, Iowa City,
Iowa, United States of America, 3 Department of Neurobiology, University of Massachusetts, Wochester, Massachusetts, United States of America
Abstract
Nuclear intermediate filament proteins, called lamins, form a meshwork that lines the inner surface of the nuclear envelope.
Lamins contain three domains: an N-terminal head, a central rod and a C-terminal tail domain possessing an Ig-fold
structural motif. Lamins are classified as either A- or B-type based on structure and expression pattern. The Drosophila
genome possesses two genes encoding lamins, Lamin C and lamin Dm0, which have been designated A- and B-type,
respectively, based on their expression profile and structural features. In humans, mutations in the gene encoding A-type
lamins are associated with a spectrum of predominantly tissue-specific diseases known as laminopathies. Linking the
disease phenotypes to cellular functions of lamins has been a major challenge. Drosophila is being used as a model system
to identify the roles of lamins in development. Towards this end, we performed a comparative study of Drosophila and
human A-type lamins. A
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