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a comparison of computational methods for identifying virulence factors比较确定毒性因子的计算方法
A Comparison of Computational Methods for Identifying
Virulence Factors
1,2 1,2,5 10 8 2 2,7 3,4
Lu-Lu Zheng , Yi-Xue Li , Juan Ding , Xiao-Kui Guo , Kai-Yan Feng , Ya-Jun Wang , Le-Le Hu ,
Yu-Dong Cai3*, Pei Hao2,6*, Kuo-Chen Chou9
1 Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan, Hubei, China, 2 Shanghai Center for
Bioinformation Technology, Shanghai, China, 3 Institute of Systems Biology, Shanghai University, Shanghai, China, 4 Department of Chemistry, College of Sciences,
Shanghai University, Shanghai, China, 5 Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China,
6 Pathogen Diagnostic Center, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China, 7 Shanghai Center for Systems Biomedicine, Shanghai
Jiaotong University, Shanghai, China, 8 Department of Medical Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of
Medicine, Shanghai, China, 9 Gordon Life Science Institute, San Diego, California, United States of America, 10 Schepens Eye Research Institute, Harvard Medical School,
Boston, Massachusetts, United States of America
Abstract
Bacterial pathogens continue to threaten public health worldwide today. Identification of bacterial virulence factors can
help to find novel drug/vaccine targets against pathogenicity. It can also help to reveal the mechanisms of the related
diseases at the molecular level. With the explosive growth in protein sequences generated in the postgenomic age, it is
highly desired to develop computation
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