原创力文档a large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2大规模的风湿性关节炎基因研究识别染色体9 q33.2协会.pdfVIP
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a large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2大规模的风湿性关节炎基因研究识别染色体9 q33.2协会
A Large-Scale Rheumatoid Arthritis Genetic Study
Identifies Association at Chromosome 9q33.2
1 1 1 1 1
Monica Chang , Charles M. Rowland , Veronica E. Garcia , Steven J. Schrodi , Joseph J. Catanese ,
2 3¤a 4 5
Annette H. M. van der Helm-van Mil , Kristin G. Ardlie , Christopher I. Amos , Lindsey A. Criswell ,
6 7 2 2 2
Daniel L. Kastner , Peter K. Gregersen , Fina A. S. Kurreeman , Rene E. M. Toes , Tom W. J. Huizinga ,
Michael F. Seldin8, Ann B. Begovich1¤b*
1 Celera, Alameda, California, United States of America, 2 Leiden University Medical Centre, Leiden, The Netherlands, 3 SeraCare Life Sciences, Cambridge, Massachusetts,
United States of America, 4 University of Texas, Houston, Texas, United States of America, 5 Rosalind Russell Medical Research Center for Arthritis, Department of
Medicine, University of California San Francisco, San Francisco, California, United States of America, 6 National Institute of Health, Bethesda, Maryland, United States of
America, 7 Feinstein Institute for Medical Research, North Shore L.I.J. Health System, Manhasset, New York, United States of America, 8 University of California Davis, Davis,
California, United States of America
Abstract
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues.
Although some genetic risk factors for RA are well-established, most notably HLA-DRB1 and PTPN22, these markers do not
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