原创力文档a longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness萎缩的纵向研究遗忘轻度认知障碍和正常老化皮质厚度所揭示.pdfVIP
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a longitudinal study of atrophy in amnestic mild cognitive impairment and normal aging revealed by cortical thickness萎缩的纵向研究遗忘轻度认知障碍和正常老化皮质厚度所揭示
A Longitudinal Study of Atrophy in Amnestic Mild
Cognitive Impairment and Normal Aging Revealed by
Cortical Thickness
1 1,3 1 1 2
Zhijun Yao , Bin Hu *, Chuanjiang Liang , Lina Zhao , Mike Jackson , the Alzheimer’s Disease
Neuroimaging Initiative
1 School of Information Science and Engineering, Lanzhou University, Lanzhou, China, 2 Birmingham City Business School, Birmingham City University, Perry Barr,
Birmingham, United Kingdom, 3 School of Computing, Telecomminications and Networks, Birmingham City University, Birmingham, United Kingdom
Abstract
In recent years, amnestic mild cognitive impairment (aMCI) has attracted significant attention as an indicator of high risk for
Alzheimer’s disease. An understanding of the pathology of aMCI may benefit the development of effective clinical
treatments for dementia. In this work, we measured the cortical thickness of 109 aMCI subjects and 99 normal controls (NC)
twice over two years. The longitudinal changes and the cross-sectional differences between the two types of participants
were explored using the vertex thickness values. The thickness of the cortex in aMCI was found significantly reduced in both
longitudinal and between-group comparisons, mainly in the temporal lobe, superolateral parietal lobe and some regions of
the frontal cortices. Compared to NC, the aMCI showed a significantly high atrophy rate in the left lateral temporal lobe and
left parahippocampal gyrus over two years. Additionally, a significant positive correlation between brain atrophy and the
decline of Mini-Mental State Examination (MMSE) scores was also found in the left superior and left middle temporal gyrus
in aMCI. These findings demonstrated specific longitudinal spatial patterns of cortical atroph
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