原创力文档a multiparent advanced generation inter-cross to fine-map quantitative traits in arabidopsis thalianamultiparent先进一代杂交在拟南芥fine-map量化特征.pdfVIP
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a multiparent advanced generation inter-cross to fine-map quantitative traits in arabidopsis thalianamultiparent先进一代杂交在拟南芥fine-map量化特征
A Multiparent Advanced Generation Inter-Cross to Fine-
Map Quantitative Traits in Arabidopsis thaliana
1,2 3 3 2 4
Paula X. Kover *, William Valdar , Joseph Trakalo , Nora Scarcelli , Ian M. Ehrenreich , Michael D.
4 3 3
Purugganan , Caroline Durrant , Richard Mott
1 Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom, 2 Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom,
3 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, 4 Center for Genomics and Systems Biology, New York University, New York,
New York, United States of America
Abstract
Identifying natural allelic variation that underlies quantitative trait variation remains a fundamental problem in genetics.
Most studies have employed either simple synthetic populations with restricted allelic variation or performed association
mapping on a sample of naturally occurring haplotypes. Both of these approaches have some limitations, therefore
alternative resources for the genetic dissection of complex traits continue to be sought. Here we describe one such
alternative, the Multiparent Advanced Generation Inter-Cross (MAGIC). This approach is expected to improve the precision
with which QTL can be mapped, improving the outlook for QTL cloning. Here, we present the first panel of MAGIC lines
developed: a set of 527 recombinant inbred lines (RILs) descended from a heterogeneous stock of 19 intermated accessions
of the plant Arabidopsis thaliana. These lines and the 19 founders were genotyped with 1,260 single nucleotide
polymorphisms and phenotyped for develop
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