依那普利联合苯磺酸氨氯地平治疗原发性高血压疗效观察.docVIP

依那普利联合苯磺酸氨氯地平治疗原发性高血压疗效观察[摘要] 目的：探讨依那普利联合苯磺酸氨氯地平在原发性高血压治疗中的疗效。方法：选取2008年1月～2010年10月的98例原发性高血压患者为研究对象，将其随机分为对照组（苯磺酸氨氯地平组）49例和观察组（依那普利联合苯磺酸氨氯地平组）49例，后将两组患者的治疗总有效率、不良反应发生率及治疗前后的血压水平、心肌肥厚情况进行统计及比较。结果：经研究及比较发现，观察组的治疗总有效率高于对照组，心肌肥厚改善效果优于对照组，均有显著性差异（均P＜0.05），而两组不良反应发生率比较，无显著性差异（P＞0.05）。结论：依那普利联合苯磺酸氨氯地平在原发性高血压的疗效较好，值得临床推广应用。 [关键词] 原发性高血压 依那普利 苯磺酸氨氯地平 疗效 [中图分类号] R544.1[文献标识码]B [文章编号]1673-7210（2011）02（b）-056－０2 The clinical observation on the Enalapril combined with Amlodipine Besylate in treatment of essential hypertension LU Biao, HUANG Fensheng (Cure One Department, Guangzhou military Guilin sanatorium, Guangxi Zhuang Autonomous Region, Guilin 541005, China) [Abstract] Objective: To study the effects of Enalapril combined with Amlodipine Besylate in treatment of essential hypertension. Methods: 98 patients with essential hypertension from January 2008 to October 2010 were selected as research object, and all the patients were randomly divided into control group（Amlodipine Besylate group）49 cases and observation group（Enalapril combined with Amlodipine Besylate group）49 cases, then the total effective rate, incidences of adverse reactions and the blood pressure, situation of cardiac hypertrophy before and after the treatment were studied and compared. Results: The total effective rate of observation group was higher than that of control group, the improvement of cardiac hypertrophy was better than that control group, there were significant differences (all P＜0.05), but the incidences of adverse reactions of the two groups were compared, there were no significant differences (P＞0.05). Conclusion: The effect of Enalapril combined with Amlodipine Besylate in essential hypertension is better， and it deserves further clinical applications. [Key words] Essential hypertension; Enalapril; Amlodipine Besylate; Effects 在绝大多数患者中，高血压的病因不明，称之为原发性高血压，占总高血压患者的95％以上。本病为长期慢性疾病，如控制不好可影响重要脏器如心、脑、肾的功能，最终可导致这些器官的功能衰竭[1]。因此控制好患者的血压非常重要。本文中就依那普利联合苯磺酸氨氯地平在原发性高血压治疗中的疗效进行研究，现