rho rock信号通路在原发性高血压肾纤维化中作用（Role of Rho and rock signaling pathway in primary hypertension and renal fibrosis）.docVIP

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rho rock信号通路在原发性高血压肾纤维化中作用（Role of Rho and rock signaling pathway in primary hypertension and renal fibrosis）.doc

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rho rock信号通路在原发性高血压肾纤维化中作用（Role of Rho and rock signaling pathway in primary hypertension and renal fibrosis）

rho rock信号通路在原发性高血压肾纤维化中作用（Role of Rho and rock signaling pathway in primary hypertension and renal fibrosis） The role of rho/rock signaling pathway in renal fibrosis of essential hypertension This article source: paper / [Abstract] Objective To investigate the role of rho/rock signaling pathway in the pathogenesis of primary hypertension with renal fibrosis. Methods 31 cases of hypertensive patients, according to the 24 h urinary albumin excretion rate (UAER) were divided into normal albuminuria group (a group), 11 patients with microalbuminuria group (B group) and 10 cases of uremia group (C group) 10 cases and 10 normal individuals were selected as control group. Using enzyme-linked immunosorbent assay (ELISA) serum transforming growth factor beta (TGF beta?), matrix metalloproteinase 9 (MMP? 9) and Rho associated coiled coil containing protein kinase 1 (rock? 1), analysis of TGF, MMP, beta?? 9 rock correlation between the 1 groups in? Between the expression and the three. Results compared with the control group, a, B, C group TGF beta, MMP?? 9, rock? 1 serum concentrations were significantly increased (f=14.498 ~ 126.037, q=3.222 ~ 20.617; plt, 0.05; B, 0.01); group C beta and rock TGF?? 1 serum concentration was significantly higher than that of a group (q=4.797 - 17.636, P 0.01), B, C group TGF beta, rock?? 1 serum concentrations had no significant difference (q=0.612, 1.175, P 0.05); group B MMP? 9 serum concentration group was significantly higher than a, C (q=4.799, 5.959, P 0.01), while the difference between a and C was not significant (q=1.299, P 0.05). Serum TGF, beta, and MMP, 9, TGF, beta, and rock, 1, MMP, 9, and rock, 1, were positively correlated (r=0.381 to 0.652, P 0.05). Conclusion rho/rock signaling pathway may be involved in the pathogenesis of hypertensive renal fibrosis. Keywords kidney; fibrosis; hypertension; rho/rock signaling pathway; transforming growth factor beta; matrix metalloproteinases; Abstract Objective To investigate the e