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连锁分析与遗传学作图
第二章 连锁分析与染色体作图
Linkage and Chromosome Mapping
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The chromosomal basis of Mendelism
T.H.Morgan
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Thomas H. Morgan (1866-1945)
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Morgan found a mutant white eye fruit fly
What would
you do on
this fly?
1910
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The reciprocal cross gave different
results with the original cross.
Morgan hypothesized that the recessive
white allele of the first white eye fly
located on the X chromosome.
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第一节 伴性遗传
(Sex chromosomes
and sex-linked inheritance)
一、性染色体 Sex Chromosomes
Sex chromosomes: Chromosomes that are
connected with the determination of sex
( XY ZW )
All the other chromosomes in the genome
are called autosomes (A)
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Hemizygous (半合子): Genes in the differential regions of
sex chromosomes
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Evolution of the Y
chromosome
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Sex Is Determined by a Number
of Different Mechanisms
Chromosomal Sex-Determining Systems
XX-XY :
ZZ-ZW: birds, snakes, butterflies, some
amphibians, and some fishes.
XX-XO : grasshoppers, C.
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