非核苷类HIV-1逆转录酶抑制剂探究进展(待续).docVIP

非核苷类HIV-1逆转录酶抑制剂探究进展(待续)[摘要] 逆转录酶是设计抗艾滋病药物研究的选择性的靶点,逆转录酶抑制剂主要分为核苷类和非核苷类两大类,本文主要根据化学结构类型综述近年来非核苷类HIV-1逆转录酶抑制剂的研究进展。 [关键词] 药物化学;抗艾滋病药物;HIV-1逆转录酶;非核苷类;酶抑制剂 [中图分类号] R914[文献标识码]A [文章编号]1673-7210(2010)03(b)-009-04 Research progress of nonnucleoside HIV-1 reverse transcriptase inhibitors MENG Ge (Faculty of Pharmacy, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, China) [Abstract] HIV-1 reverse transcriptase (RT) is the new selective target for designing anti-HIV-1 drugs. The HIV-1 RT inhibitors are divided into two groups, nucleosides and nonnucleosides. The research