antibody-dependent transplacental transfer of malaria blood-stage antigen using a human ex vivo placental perfusion model锁定经胎盘的转让使用人类疟疾blood-stage抗原体外胎盘灌注模型.pdfVIP

Antibody-Dependent Transplacental Transfer of Malaria Blood-Stage Antigen Using a Human Ex Vivo Placental Perfusion Model 1 1 3 4 4 5 Karen May , Markus Grube , Indu Malhotra , Carole A. Long , Sanjay Singh , Kishor Mandaliya , Werner 1 2 6 3,7 Siegmund , Christoph Fusch , Henning Schneider , Christopher L. King * 1 Department of Pharmacology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany, 2 Department of Pediatrics, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany, 3 Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America, 4 Malaria Vaccine Development Unit and Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, Maryland, United States of America, 5 Pathology Services, Kenyan Ministry of Health, Mombasa General Hospital, Mombasa, Kenya, 6 Department of Obstetrics and Gynecology, University of Berne, Berne, Switzerland, 7 Louis B. Stokes Veterans Affairs Medical Center, Cleveland, Ohio, United States of America Abstract Prenatal exposure to allergens or antigens released by infections during pregnancy can stimulate an immune response or induce immunoregulatory networks in the fetus affecting susceptibility to infection and disease later in life. How antigen crosses from the maternal to fetal environment is poorly understood. One hypothesis is that transplacental antigen transfer occurs as immune complexes, via receptor-mediated transport across the syncytiotrophoblastic membrane and endothelium of vessels in fetal villi. This hypothesis has nev