anticancer activities of six selected natural compounds of some cameroonian medicinal plants六选天然化合物的抗癌活动一些喀麦隆药用植物.pdfVIP

Anticancer Activities of Six Selected Natural Compounds of Some Cameroonian Medicinal Plants 1,2 3 4 3 2 Victor Kuete , Hippolyte K. Wabo , Kenneth O. Eyong , Michel T. Feussi , Benjamin Wiench , Benjamin 2 3 4 2 Krusche , Pierre Tane , Gabriel N. Folefoc , Thomas Efferth * 1 Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon, 2 Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Mainz, Germany, 3 Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon, 4 Department of Organic ´ ´ Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon Abstract Background: Natural products are well recognized as sources of drugs in several human ailments. In the present work, we carried out a preliminary screening of six natural compounds, xanthone V1 (1); 2-acetylfuro-1,4-naphthoquinone (2); physcion (3); bisvismiaquinone (4); vismiaquinone (5); 1,8-dihydroxy-3-geranyloxy-6-methylanthraquinone (6) against MiaPaCa-2 pancreatic and CCRF-CEM leukemia cells and their multidrug-resistant subline, CEM/ADR5000. Compounds 1 and 2 were then tested in several other cancer cells and their possible mode of action were investigated. Methodology/Findings: The tested compounds were previously isolated from the Cameroonian medicinal plants Vismia laurentii (1, 3, 4, 5 and 6) and Newbouldia laevis (2). The preliminary cytotoxicity results allowed the selection of xanthone V1 and 2-acetylfuro-1,4-naphthoquinone,