原创力文档arabidopsis tfl2lhp1 specifically associates with genes marked by trimethylation of histone h3 lysine 27拟南芥tfl2lhp1 trimethylation专门associates的基因标记的组蛋白h3赖氨酸27.pdfVIP
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arabidopsis tfl2lhp1 specifically associates with genes marked by trimethylation of histone h3 lysine 27拟南芥tfl2lhp1 trimethylation专门associates的基因标记的组蛋白h3赖氨酸27
Arabidopsis TFL2/LHP1 Specifically Associates
with Genes Marked by Trimethylation
of Histone H3 Lysine 27
1[ 2[ 1 2,3 2
Franziska Turck , Franc¸ois Roudier , Sara Farrona , Marie-Laure Martin-Magniette , Elodie Guillaume ,
2 ´ 2 4 1* 2*
Nicolas Buisine , Severine Gagnot , Robert A. Martienssen , George Coupland , Vincent Colot
¨ ¨ ´ ´ ´ ´
1 Abteilung Entwicklungsbiologie der Pflanzen, Max Planck Institut fur Zuchtungsforschung, Cologne, Germany, 2 Unite de Recherche en Genomique Vegetale, CNRS
´ ´ ´
UMR8114, INRA UMR1165, Universite d’Evry Val d’Essonne, Evry, France, 3 Mathematiques et Informatiques Appliquees, AgroParisTech, INRA UMR518, Paris, France, 4 Cold
Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
TERMINAL FLOWER 2/LIKE HETEROCHROMATIN PROTEIN 1 (TFL2/LHP1) is the only Arabidopsis protein with overall
sequence similarity to the HETEROCHROMATIN PROTEIN 1 (HP1) family of metazoans and S. pombe. TFL2/LHP1
represses transcription of numerous genes, including the flowering-time genes FLOWERING LOCUS T (FT) and
FLOWERING LOCUS C (FLC), as well as the floral organ identity genes AGAMOUS (AG) and APETALA 3 (AP3). These genes
are also regulated by proteins of the Polycomb repressive complex 2 (PRC2), and it has been proposed that TFL2/LHP1
represents a potenti
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