association of the ctla4 gene with graves disease in the chinese han populationctla4基因协会与中国汉族人群的甲状腺机能亢进.pdfVIP

Association of the CTLA4 Gene with Graves’ Disease in the Chinese Han Population 1. 1. 1. 1 1 2 Shuang-Xia Zhao , Chun-Ming Pan , Huang-Ming Cao , Bing Han , Jing-Yi Shi , Jun Liang , Guan-Qi 3 4 5 1 6 1 Gao , Yong-De Peng , Qing Su , Jia-Lun Chen , Jia-Jun Zhao *, Huai-Dong Song * 1 Ruijin Hospital, State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Shanghai Jiao Tong University (SJTU) School of Medicine, Shanghai, China, 2 Department of Endocrinology, Fourth Hospital of Xuzhou, Xuzhou, Jiangsu, China, 3 Department of Endocrinology, The People’s Hospital of Linyi, Linyi, Shandong, China, 4 Department of Endocrinology, The First People’s Hospital, Shanghai Jiao Tong University (SJTU) School of Medicine, Shanghai, China, 5 Department of Endocrinology, Xin Hua Hospital, Shanghai Jiao Tong University (SJTU) School of Medicine, Shanghai, China, 6 Department of Endocrinology, Shandong Province Hospital, Shandong University, Jinan, Shandong, China Abstract To determine whether genetic heterogeneity exists in patients with Graves’ disease (GD), the cytotoxic T-lymphocyte associated 4 (CTLA-4) gene, which is implicated a susceptibility gene for GD by considerable genetic and immunological evidence, was used for association analysis in a Chinese Han cohort recruited from various geographic regions. Our association study for the SNPs in the CTLA4 gene in 2640 GD patients and 2204 control subjects confirmed that CTLA4 is the susceptibility gene for GD in the Chinese Han population. Moreover, the logistic regression