association of the myostatin gene with obesity, abdominal obesity and low lean body mass and in non-diabetic asian indians in north india协会的肌肉生长抑制素基因与肥胖,腹部肥胖和低瘦体重和非糖尿病亚洲印第安人在北印度.pdfVIP

Association of the Myostatin Gene with Obesity, Abdominal Obesity and Low Lean Body Mass and in Non- Diabetic Asian Indians in North India 1,2,3 4 4,5 2 3 Surya Prakash Bhatt , Priyanka Nigam , Anoop Misra *, Randeep Guleria , Kalpana Luthra , S. K. Jain6, M. A. Qadar Pasha7 1 Department of Medicine, All India Institute of Medical Sciences, New Delhi, India, 2 Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India, 3 Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India, 4 Diabetic Foundation (India) and National Diabetes Obesity and Cholesterol Foundation (N-DOC), New Delhi, India, 5 Fortis C-DOC Center of Excellence for Diabetes, Metabolic Diseases, and Endocrinology, Chirag Enclave, New Delhi, India, 6 Department of Biotechnology, Jamia Hamdard, New Delhi, India, 7 Institute of Genomics and Integrative Biology, Delhi, India Abstract Background: To determine the association of the A55T and K153R polymorphisms of the Myostatin gene with obesity, abdominal obesity and lean body mass (LBM) in Asian Indians in north India. Materials and Methods: A total of 335 subjects (238 men and 97 women) were assessed for anthropometry, % body fat (BF), LBM and biochemical parameters. Associations of Myostatin gene polymorphisms were evaluated with anthropometric, body composition and biochemical parameters. In A55T polymorphism, BMI (p = 0.04), suprailiac skinfold (p = 0.05), total skinfold (p = 0.008), %BF (p = 0.002) and total fat mass (p = 0.003) were highest and % LBM (p = 0.03) and total LBM (Kg) were lowest (p = 0.04) in subjects with Thr/Thr genotype as compared to other genotypes. Association analys