association study of the β2-adrenergic receptor gene polymorphisms and hypertension in the northern han chinese协会的研究β2-adrenergic受体基因多态性与高血压北方汉族.pdfVIP

Association Study of the b2-Adrenergic Receptor Gene Polymorphisms and Hypertension in the Northern Han Chinese 1. 1. 2 1 1 1 2 1 1 Yuqing Lou , Jielin Liu , Yao Li , Ya Liu , Zuoguang Wang , Kuo Liu , Hai Wu , Qiuli Niu , Wei Gu , 3 4 1 Yanhong Guo , Zhizhong Li *, Shaojun Wen * 1 Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, People’s Republic of China, 2 State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China, 3 Department of Cardiology, Peking University Third Hospital, Beijing, People’s Republic of China, 4 Emergency Center of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China Abstract Background: The b2-adrenergic receptor (ADRB2) gene has been widely researched as a candidate gene for essential hypertension (EH), but no consensus has been reached in different ethnicities. The aim of the present study was to evaluate the possible association between the ADRB2 gene polymorphisms and the EH risk in the Northern Han Chinese population. Methodology/Principal Findings: This study included 747 hypertensive subjects and 390 healthy volunteers as control subjects in the Northern Han Chinese. Genotyping was performed to identify the C-47T, A46G and C79G polymorphisms of the ADRB2 gene. G allelic frequency of A46G polymorphism was significantly higher in hypertensive subjects (P = 0.011, OR = 1.287, 95%CI [1.059–1.565]) than that in