asthma is inversely associated with helicobacter pylori status in an urban population哮喘与幽门螺杆菌状态呈负相关的城市人口.pdfVIP

Asthma Is Inversely Associated with Helicobacter pylori Status in an Urban Population 1,2 1,2 1 1 1 Joan Reibman *, Michael Marmor , Joshua Filner , Maria-Elena Fernandez-Beros , Linda Rogers , Guillermo I. Perez-Perez1, Martin J. Blaser1 1 Department of Medicine, New York University School of Medicine, New York City, New York, United States of America, 2 Department of Environmental Medicine, New York University School of Medicine, New York City, New York, United States of America Abstract Background: Microbial exposures have been suggested to confer protection from allergic disorders and reduced exposures to gastrointestinal microbiota have been proposed as an explanation for the increase in asthma prevalence. Since the general prevalence of Helicobacter pylori has been decreasing, we hypothesized that H. pylori serostatus would be inversely related to the presence of asthma. Methods: Adults were recruited to participate in the New York University (NYU)/Bellevue Asthma Registry in New York City. Adult asthma cases (N = 318) and controls (N = 208) were identified and serum IgG antibodies to H. pylori whole cell antigens or the immunodominant CagA antigen were measured. Results: As expected, the asthma cases and controls differed with respect to atopy and lung function. Seropositivity to H. pylori or CagA antigen was present in 47.1% of the total case and control study population. Asthma was inversely associated with CagA seropositivity (OR = 0.57, 95% CI = 0.36–0.89). Median age of onset of asthma (doctor’s diagnosis) was older (21 years) among individuals with CagA+ strains than among H. pylori- individuals (11 years) (p = 0.006). Conclusion: These data are consistent with the h