area disease estimation based on sentinel hospital records区疾病估计基于哨点医院的记录.pdfVIP

Area Disease Estimation Based on Sentinel Hospital Records 1 2 1 3 4 5 Jin-Feng Wang *, Ben Y. Reis , Mao-Gui Hu , George Christakos , Wei-Zhong Yang , Qiao Sun , 4 1 4 6 7 Zhong-Jie Li , Xiao-Zhou Li , Sheng-Jie Lai , Hong-Yan Chen , Dao-Chen Wang 1 State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China, 2 Harvard Medical School, Children’s Hospital Boston, Boston, Massachusetts, United States of America, 3 Department of Geography, San Diego State University, San Diego, California, United States of America, 4 Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention (CDC), Beijing, China, 5 Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai, China, 6 School of Environmental Sciences, University of Liverpool, Liverpool, United Kingdom, 7 MGS, Manchester, United Kingdom Abstract Background: Population health attributes (such as disease incidence and prevalence) are often estimated using sentinel hospital records, which are subject to multiple sources of uncertainty. When applied to these health attributes, commonly used biased estimation techniques can lead to false conclusions and ineffective disease intervention and control. Although some estimators can account for measurement error (in the form of white noise, usually after de-trending), most mainstream health statistics techniques cannot generate unbiased and minimum error variance estimates when th