原创力文档atrial natriuretic peptide regulates ca2+ channel in early developmental cardiomyocytes心房利钠肽调节钙离子通道在发育早期心肌细胞.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
atrialnatriureticpeptideregulatesca2channelinearlydevelopmentalcardiomyocytes心房利钠肽调节钙离子通道在发育早期心肌细胞
Atrial Natriuretic Peptide Regulates Ca2+ Channel in Early
Developmental Cardiomyocytes
1 1 1 1 1 2 ¨
Lin Miao , Min Wang , Wen-Xuan Yin , Qi Yuan , Ying-Xiao Chen , Bernd Fleischmann , Jurgen
3 1
Hescheler *, Guangju Ji *
1 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2 Institute of Physiology, University of Bonn, Bonn,
¨
Germany, 3 Institute of Neurophysiology, University of Cologne, Koln, Germany
Abstract
Background: Cardiomyocytes derived from murine embryonic stem (ES) cells possess various membrane currents and
signaling cascades link to that of embryonic hearts. The role of atrial natriuretic peptide (ANP) in regulation of membrane
potentials and Ca2+ currents has not been investigated in developmental cardiomyocytes.
Methodology/Principal Findings: We investigated the role of ANP in regulating L-type Ca2+ channel current (ICaL) in
different developmental stages of cardiomyocytes derived from ES cells. ANP decreased the frequency of action potentials
(APs) in early developmental stage (EDS) cardiomyocytes, embryonic bodies (EB) as well as whole embryo hearts. ANP
exerted an inhibitory effect on basal ICaL in about 70% EDS cardiomyocytes tested but only in about 30% late
developmental stage (LDS) cells. However, after stimulation of ICaL by isoproterenol (ISO) in LDS cells, ANP inhibited the
response in about 70% cells. The depression of ICaL induced by ANP was not affected by either Nv, Nitro-L-Arginine methyl
ester (L-NAME), a nitric oxide synthet
您可能关注的文档
- array-comparative genomic hybridization reveals loss of socs6 is associated with poor prognosis in primary lung squamous cell carcinomaarray-comparative基因组杂交显示亏损socs6与预后不良相关原发性肺鳞状细胞癌.pdf
- assay strategies for the discovery and validation of therapeutics targeting brugia pahangi hsp90分析治疗目标的发现和验证策略与象皮病pahangi一半.pdf
- artificial neural networks trained to detect viral and phage structural proteins人工神经网络训练来检测病毒和噬菌体结构蛋白.pdf
- assays to detect β-tubulin codon 200 polymorphism in trichuris trichiura and ascaris lumbricoides鞭虫化验检测β-tubulin 200密码子多态性trichiura和蛔虫.pdf
- assembling the marine metagenome, one cell at a time海洋metagenome组装,一个细胞.pdf
- assembly of linear nano-chains from iron oxide nanospheres with asymmetric surface chemistry从铁氧化物团簇组装线性nano-chains不对称的表面化学.pdf
- assembly of drosophila centromeric chromatin proteins during mitosis果蝇的着丝粒染色质蛋白质在有丝分裂期间.pdf
- assembly of microtubules and actomyosin rings in the absence of nuclei and spindle pole bodies revealed by a novel genetic method装配的微管和肌动球蛋白环没有细胞核和轴杆机构透露了一个新颖的基因的方法.pdf
- assembly of the murine leukemia virus is directed towards sites of cell–cell contact小鼠白血病病毒的组装指向网站的信息联系.pdf
- asic3？？ female mice with hearing deficit affects social development of pupsasic3 雌性老鼠幼崽的听力赤字影响社会发展.pdf
- atrial tachyarrhythmia in rgs5-null mice心房在rgs5-null老鼠快速性心律失常.pdf
- atr-p53 restricts homologous recombination in response to replicative stress but does not limit dna interstrand crosslink repair in lung cancer cellsatr-p53限制同源重组,以应对dna复制的压力但不限制interstrand交联修复在肺癌细胞.pdf
- at-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the cd4+cd25+high t-cell fraction危险和最近研究1型糖尿病患者增加了细胞凋亡的cd4 + cd25 + t细胞比例高.pdf
- atsofl1 and atsofl2 act redundantly as positive modulators of the endogenous content of specific cytokinins in arabidopsisatsofl1 atsofl2多余地采取积极的调节器的内生内容特定的细胞分裂素在拟南芥.pdf
- attack resilience of the evolving scientific collaboration network不断发展的科学合作网络的攻击能力.pdf
- attention increases the temporal precision of conscious perception verifying the neural-st2 model注意增加意识知觉的时间精度验证neural-st2模型.pdf
- attention deficit hyperactivity disorder in australian adults prevalence, persistence, conduct problems and disadvantage在澳大利亚成人注意缺陷多动障碍患病率、持久性,行为问题和缺点.pdf
- attentional performance, age and scholastic achievement in healthy children注意力的性能,在健康儿童年龄和学术成就.pdf
- attentional prioritization of infant faces is limited to own-race infants注意力优先级的婴儿脸仅限于自己种族婴儿.pdf
- attentive and pre-attentive processes in change detection and identification细心和pre-attentive过程改变探测和识别.pdf
文档评论（0）