beneficial effects of resistance exercise on glycemic control are not further improved by protein ingestion有益的抗阻训练对血糖控制的影响没有进一步提高蛋白质摄入.pdfVIP

Beneficial Effects of Resistance Exercise on Glycemic Control Are Not Further Improved by Protein Ingestion 1,2 3 1 1 3 Leigh Breen , Andrew Philp , Christopher S. Shaw , Asker E. Jeukendrup , Keith Baar , Kevin D. Tipton1,4* 1 School of Sport and Exercise Sciences, University of Birmingham, Birmingham, United Kingdom, 2 Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada, 3 Functional Molecular Biology Lab, Neurobiology, Physiology and Behaviour, University of California Davis, Davis, California, United States of America, 4 Department of Sports Studies, University of Stirling, Stirling, United Kingdom Abstract Purpose: To investigate the mechanisms underpinning modifications in glucose homeostasis and insulin sensitivity 24 h after a bout of resistance exercise (RE) with or without protein ingestion. Methods: Twenty-four healthy males were assigned to a control (CON; n = 8), exercise (EX; n = 8) or exercise plus protein condition (EX+PRO; n = 8). Muscle biopsy and blood samples were obtained at rest for all groups and immediately post-RE (75% 1RM, 8 610 repetitions of leg-press and extension exercise) for EX and EX+PRO only. At 24 h post-RE (or post-resting biopsy for CON), a further muscle biopsy was obtained. Participants then consumed an oral glucose load (OGTT) containing 2 g of [U-13 2 C] glucose during an infusion of 6, 6-[ H ] glucose. Blood samples were obtained every 10 min for 2 h to 2 determine glucose kinetics. EX+PRO ingested an additional 25 g of intact whey protein with the OGTT. A final biopsy sample was obtained at the end of the OGTT. Results: F