beneficial metabolic effects of 2′,3′,5′-tri-acetyl-n6- (3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters有益的代谢影响2u2032,3u2032,5u2032-tri-acetyl-n6u2014u2014(3-hydroxylaniline)腺苷在肝脏和血浆hyperlipidemic仓鼠.pdfVIP

Beneficial Metabolic Effects of 29,3 9,5 9-tri-acetyl-N - (3- 6 Hydroxylaniline) Adenosine in the Liver and Plasma of Hyperlipidemic Hamsters Yang Sun., Zeqin Lian., Chunying Jiang, Yinghong Wang*, Haibo Zhu* State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Abstract Background: Pharmaceutical research of hyperlipidemia has been commonly pursued using traditional approaches. However, unbiased metabonomics attempts to explore the metabolic signature of hyperlipidemia in a high-throughput manner to understand pathophysiology of the disease process. Methodology/Principal Findings: As a new way, we performed 1H NMR-based metabonomics to evaluate the beneficial effects of 29,3 9,5 9-tri-acetyl-N - (3-hydroxylaniline) adenosine (WS070117) on plasma and liver from hyperlipidemic 6 Syrian golden hamsters. Both plasma and liver profiles provided a clearer distinction between the control and hyperlipidemic hamsters. Compared to control animals, hyperlipidemic hamsters showed a higher content of lipids (triglyceride and cholesterol), lactate and alanine together with a lower content of choline-containing compounds (e.g., phosphocholine, phosphatidylcholine, and glycerophosphocholine) and betaine. As a result, metabonomics-based findings such as the PCA and OPLS-DA plotting of metabolic state and analysis of potential biomarkers in plasma and liver correlated well to the assessment of biochemical assays, Oi