原创力文档bim mediates egfr tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic egfr mutationsbim调节表皮生长因子受体酪氨酸激酶inhibitor-induced细胞凋亡与致癌肺癌表皮生长因子受体突变.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
bim mediates egfr tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic egfr mutationsbim调节表皮生长因子受体酪氨酸激酶inhibitor-induced细胞凋亡与致癌肺癌表皮生长因子受体突变
PLoS MEDICINE
BIM Mediates EGFR Tyrosine Kinase Inhibitor-
Induced Apoptosis in Lung Cancers with
Oncogenic EGFR Mutations
1 ´ 2 3 1 1 3
Daniel B. Costa , Balazs Halmos , Amit Kumar , Susan T. Schumer , Mark S. Huberman , Titus J. Boggon ,
1 1*
Daniel G. Tenen , Susumu Kobayashi
1 Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 2 University Hospitals
of Cleveland and Case Western Reserve University, Cleveland, Ohio, United States of America, 3 Department of Pharmacology, Yale University School of Medicine, New
Haven, Connecticut, United States of America
Funding: See section at end of A B S T R A C T
manuscript.
Competing Interests: The authors
have declared that no competing Background
interests exist.
Epidermal growth factor receptor (EGFR) mutations are present in the majority of patients
Academic Editor: Ingo K. with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase inhibitors (TKIs)
Mellinghoff, University of California gefitinib or erlotinib. These EGFR-dependent tumors eventually become TKI resistant, and the
Los Angeles, United States of
America common secondary T790M mutation accounts for half the tumors with acquired resistance to
gefitinib. However, the key proapoptotic proteins involved in TKI-induced cell death and other
Citation: Costa DB, Halmos B, Kumar
A, Schumer ST, Huberman MS, et al. secondary mutations involved in
您可能关注的文档
- at-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the cd4+cd25+high t-cell fraction危险和最近研究1型糖尿病患者增加了细胞凋亡的cd4 + cd25 + t细胞比例高.pdf
- atsofl1 and atsofl2 act redundantly as positive modulators of the endogenous content of specific cytokinins in arabidopsisatsofl1 atsofl2多余地采取积极的调节器的内生内容特定的细胞分裂素在拟南芥.pdf
- attack resilience of the evolving scientific collaboration network不断发展的科学合作网络的攻击能力.pdf
- attention increases the temporal precision of conscious perception verifying the neural-st2 model注意增加意识知觉的时间精度验证neural-st2模型.pdf
- attention deficit hyperactivity disorder in australian adults prevalence, persistence, conduct problems and disadvantage在澳大利亚成人注意缺陷多动障碍患病率、持久性,行为问题和缺点.pdf
- attentional performance, age and scholastic achievement in healthy children注意力的性能,在健康儿童年龄和学术成就.pdf
- attentional prioritization of infant faces is limited to own-race infants注意力优先级的婴儿脸仅限于自己种族婴儿.pdf
- attentive and pre-attentive processes in change detection and identification细心和pre-attentive过程改变探测和识别.pdf
- atpv42a and atpv42b redundantly regulate reproductive development in arabidopsis thalianaatpv42a和atpv42b多余地调节拟南芥的繁殖发展.pdf
- attaching and effacing escherichia coli downregulate dna mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans附加和消除大肠杆菌表达下调dna错配修复蛋白在体外,在人类与结直肠腺癌相关联.pdf
- bimodal and hysteretic expression in mammalian cells from a synthetic gene circuit双峰和滞后表达基因在哺乳动物细胞合成电路.pdf
- bim-mediated akt phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells砷trioxide-induced bim-mediated一种蛋白激酶磷酸化是一个关键的调制器在防cisplatin-sensitive和卵巢癌细胞凋亡.pdf
- binary is typing for staphylococcus aureus二进制输入为金黄色葡萄球菌.pdf
- binding free energy landscape of domain-peptide interactions结合自由能景观domain-peptide交互.pdf
- binding of nir-conpk and nir-6t to astrocytomas and microglial cells evidence for a protein related to tspo绑定nir-conpk和nir-6t星形细胞瘤和小胶质细胞的证据tspo相关蛋白质.pdf
- binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry绑定的单纯疱疹病毒1型病毒导致细胞内信号的感应没有病毒的条目.pdf
- binding leverage as a molecular basis for allosteric regulation绑定杠杆作为变构调节的分子基础.pdf
- binding of pramipexole to extrastriatal dopamine d2d3 receptors in the human brain a positron emission tomography study using 11c-flb 457绑定的pramipexole extrastriatal人类大脑中的多巴胺d2d3受体使用11 c-flb 457正电子发射断层扫描研究.pdf
- bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switchingbindarit抑制人类冠状动脉平滑肌细胞增殖,迁移和表型转换.pdf
- bile acid-induced arrhythmia is mediated by muscarinic m2 receptors in neonatal rat cardiomyocytes胆汁段心律失常是在新生大鼠心肌细胞毒蕈碱的m2受体介导的.pdf
文档评论（0）