原创力文档biocompatibility and biodegradation studies of subconjunctival implants in rabbit eyes兔眼结膜下植入物的生物相容性和生物降解研究.pdfVIP
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biocompatibility and biodegradation studies of subconjunctival implants in rabbit eyes兔眼结膜下植入物的生物相容性和生物降解研究
Biocompatibility and Biodegradation Studies of
Subconjunctival Implants in Rabbit Eyes
1. 2,3. 3 2 3 1
Yan Peng , Marcus Ang , Selin Foo , Wing Sum Lee , Zhen Ma , Subbu S. Venkatraman *, Tina T.
Wong1,2,3,4*
1 School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore, 2 Singapore National Eye Centre, Singapore, Singapore,
3 Singapore Eye Research Institute, Singapore, Singapore, 4 Department of Ophthalmology, Yong Yoo Lin School of Medicine, National University of Singapore, Singapore,
Singapore
Abstract
Sustained ocular drug delivery is difficult to achieve. Most drugs have poor penetration due to the multiple physiological
barriers of the eye and are rapidly cleared if applied topically. Biodegradable subconjunctival implants with controlled drug
release may circumvent these two problems. In our study, two microfilms (poly [d,l-lactide-co-glycolide] PLGA and poly[d,l-
lactide-co-caprolactone] PLC were developed and evaluated for their degradation behavior in vitro and in vivo. We also
evaluated the biocompatibility of both microfilms. Eighteen eyes (9 rabbits) were surgically implanted with one type of
microfilm in each eye. Serial anterior-segment optical coherence tomography (AS-OCT) scans together with serial slit-lamp
microscopy allowed us to measure thickness and cross-sectional area of the microfilms. In vitro studies revealed bulk
degradation kinetics for both microfilms, while in vivo studies demonstrated surface erosion kinetics. Serial slit-lamp
microscopy revealed no significant inflammation or vascularization in both types of implants (mean increase in vascularity
grade PLGA50/50 1260.5% vs. PLC70/30 15 60.6%; P = 0.91) over
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