cepred predicting the co-expression patterns of the human intronic micrornas with their host genes期预测人类的co-expression模式intronic microrna与宿主的基因.pdfVIP

Cepred: Predicting the Co-Expression Patterns of the Human Intronic microRNAs with Their Host Genes 1,2 1,2 3 4 5 1,2 Dong Wang , Ming Lu , Jing Miao , Tingting Li , Edwin Wang , Qinghua Cui * 1 Department of Medical Informatics, Peking University Health Science Center, Beijing, China, 2 MOE Key Laboratory of Molecular Cardiology, Peking University, Beijing, China, 3 Department of Pediatrics, Peking University First Hospital, Beijing, China, 4 MOE key laboratory of Bioinformatics, Tsinghua University, Beijing, China, ´ 5 Computational Chemistry and Biology Group, Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, Canada Abstract Identifying the tissues in which a microRNA is expressed could enhance the understanding of the functions, the biological processes, and the diseases associated with that microRNA. However, the mechanisms of microRNA biogenesis and expression remain largely unclear and the identification of the tissues in which a microRNA is expressed is limited. Here, we present a machine learning based approach to predict whether an intronic microRNA show high co-expression with its host gene, by doing so, we could infer the tissues in which a microRNA is high expressed through the expression profile of its host gene. Our approach is able to achieve an accuracy of 79% in the leave-one-out cross validation and 95% on an independent testing dataset. We further estimated our method through comparing the predicted tissue specific microRNAs and the tissue specific microRNAs identified by biological experimen