原创力文档characterization of the early proliferative response of the rodent bladder to subtotal cystectomy a unique model of mammalian organ regeneration描述早期的增殖反应的啮齿动物膀胱切除术小计一个独特的哺乳动物器官再生的模型.pdfVIP
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characterization of the early proliferative response of the rodent bladder to subtotal cystectomy a unique model of mammalian organ regeneration描述早期的增殖反应的啮齿动物膀胱切除术小计一个独特的哺乳动物器官再生的模型
Characterization of the Early Proliferative Response of
the Rodent Bladder to Subtotal Cystectomy: A Unique
Model of Mammalian Organ Regeneration
1 2 2 2 2
Charles C. Peyton , David Burmeister , Bryon Petersen , Karl-Erik Andersson , George Christ *
1 Department of Urology, Wake Forest Baptist Medical Center, Winston Salem, North Carolina, United States of America, 2 Institute for Regenerative Medicine, Wake
Forest University, Winston Salem, North Carolina, United States of America
Abstract
Subtotal cystectomy (STC; surgical removal of ,75% of the rat urinary bladder) elicits a robust proliferative response
resulting in complete structural and functional bladder regeneration within 8-weeks. The goal of these studies was to
characterize the early cellular response that mediates this regenerative phenomenon, which is unique among mammalian
organ systems. STC was performed on eighteen 12-week-old female Fischer F344 rats. At 1, 3, 5 and 7-days post-STC, the
bladder was harvested 2-hours after intraperitoneal injection of bromodeoxyuridine (BrdU). Fluorescent BrdU labeling was
quantified in cells within the urothelium, lamina propria (LP), muscularis propria (MP) and serosa. Cell location was
confirmed with fluorescently co-labeled cytokeratin, vimentin or smooth muscle actin (SMA), to identify urothelial,
interstitial and smooth muscle cells, respectively. Expression of sonic hedgehog (Shh), Gli-1 and bone morphogenic factor-4
(BMP-4) were evaluated with immunochemistry. Three non-operated rats injected with BrdU served as controls. Less than
1% of cells in the bladder wall were labeled with BrdU in control bladders, but this percentage sign
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