原创力文档chemical analysis and risk assessment of diethyl phthalate in alcoholic beverages with special regard to unrecorded alcohol邻苯二甲酸二乙酯的化学分析和风险评估酒精饮料有特殊方面没有记录的酒精.pdfVIP
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chemical analysis and risk assessment of diethyl phthalate in alcoholic beverages with special regard to unrecorded alcohol邻苯二甲酸二乙酯的化学分析和风险评估酒精饮料有特殊方面没有记录的酒精
Chemical Analysis and Risk Assessment of Diethyl
Phthalate in Alcoholic Beverages with Special Regard to
Unrecorded Alcohol
1 1 ¨ 2,3,4 1
Jenny Leitz , Thomas Kuballa , Jurgen Rehm , Dirk W. Lachenmeier *
¨
1 Chemisches und Veterinaruntersuchungsamt (CVUA) Karlsruhe, Karlsruhe, Germany, 2 Centre for Addiction and Mental Health (CAMH), Toronto, Canada, 3 Dalla Lana
School of Public Health, University of Toronto, Toronto, Canada, 4 Institute for Clinical Psychology and Psychotherapy, TU Dresden, Dresden, Germany
Abstract
Background: Phthalates are synthetic compounds with a widespread field of applications. For example, they are used as
plasticizers in PVC plastics and food packaging, or are added to personal care products. Diethyl phthalate (DEP) may be used
to denature alcohol, e.g., for cosmetic purposes. Public health concerns of phthalates include carcinogenic, teratogenic,
hepatotoxic and endocrine effects. The aim of this study was to develop and validate a method for determining phthalates
in alcohol samples and to provide a risk assessment for consumers of such products.
Methodology/Principal Findings: A liquid-liquid extraction procedure was optimized by varying the following parameters:
type of extraction solvent (cyclohexane, n-hexane, 1,1,2-trichlorotrifluoroethane), the ratio extraction solvent/sample
volume (1:1 to 50:1) and the number of extraction repetitions (1–10). The best extraction yield (99.9%) was achieved with
the solvent 1,1,2-trichlorotrifluoroethane, an extraction solvent volume/sample volume ratio of 10:1 and a double
extraction. For quantification, gas chromatography/mass spectrometry with deuterated internal standards was used.
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