chromosome cohesion a cycle of holding together and falling apart染色体凝聚力周期的维系和分崩离析.pdfVIP

Open access, freely available online Primer Chromosome Cohesion: A Cycle of Holding Together and Falling Apart Jennifer Gerton ll organisms have mechanisms to ensure that dividing cells produce new cells with the proper number of Achromosomes. The dividing cell closely monitors that chromosomes are copied exactly once and then DOI: 10.1371/journal.pbio.0030094.g001 distributed correctly to daughter cells. After replication, Figure 1. Cohesin Sites for Sister Chromatids of Chromosome I in S. the chromosomes (now comprising two chromatids) align cerevisiae at the center of the cell, and are attached to a structure Cohesin sites (red ovals) are concentrated at the centromere/ known as the spindle apparatus. A key point of attachment pericentric region (where the two chromatids are “pinched”), but is the centromere, a characteristic constriction carried by also occur along the arms of the chromatids. each chromosome. The spindle, which is composed of proteins: Smc1, Smc3, Scc1/Mcd1 (also known as kleisin), microtubules, pulls the chromatids apart so that two complete and Scc3 (SA2). The Smc (structural maintenance of sets of chromosomes are gathered together at each pole of the chromosomes) proteins form intramolecular coiled coils cell, which can then divide. Cohesion between chromosome that have been observe