原创力文档chromosome 7 and 19 trisomy in cultured human neural progenitor cells染色体7和19三染色体细胞在培养人类神经祖细胞.pdfVIP
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chromosome 7 and 19 trisomy in cultured human neural progenitor cells染色体7和19三染色体细胞在培养人类神经祖细胞
Chromosome 7 and 19 Trisomy in Cultured Human
Neural Progenitor Cells
1,2 3 1,2 1,2 4
Dhruv Sareen , Erin McMillan , Allison D. Ebert , Brandon C. Shelley , Julie A. Johnson , Lorraine F.
Meisner4, Clive N. Svendsen1,2*
1 Department of Neurology, University of Wisconsin School of Medicine and Public Health, Wisconsin Institutes for Medical Research (WIMR), Madison, Wisconsin, United
States of America, 2 The Stem Cell and Regenerative Medicine Center, University of Wisconsin, Madison, Wisconsin, United States of America, 3 The Waisman Center,
University of Wisconsin, Madison, Wisconsin, United States of America, 4 Cell Line Genetics, LLC, Madison, Wisconsin, United States of America
Abstract
Background: Stem cell expansion and differentiation is the foundation of emerging cell therapy technologies. The potential
applications of human neural progenitor cells (hNPCs) are wide ranging, but a normal cytogenetic profile is important to
avoid the risk of tumor formation in clinical trials. FDA approved clinical trials are being planned and conducted for hNPC
transplantation into the brain or spinal cord for various neurodegenerative disorders. Although human embryonic stem cells
(hESCs) are known to show recurrent chromosomal abnormalities involving 12 and 17, no studies have revealed
chromosomal abnormalities in cultured hNPCs. Therefore, we investigated frequently occurring chromosomal abnormalities
in 21 independent fetal-derived hNPC lines and the possible mechanisms triggering such aberrations.
Methods and Findings: While most hNPC lines were karyotypically normal, G-band karyotypi
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