原创力文档- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
c-myc is required for maintenance of glioma cancer stem cells原癌基因的维护需要神经胶质瘤肿瘤干细胞
c-Myc Is Required for Maintenance of Glioma Cancer
Stem Cells
Jialiang Wang1,5, Hui Wang2,5, Zhizhong Li2,5, Qiulian Wu1,5, Justin D. Lathia1,5, Roger E. McLendon3,5,
Anita B. Hjelmeland1,5, Jeremy N. Rich1,2,4,5,6*
1 Department of Surgery, Duke University, Durham, North Carolina, United States of America, 2 Department of Pharmacology and Cancer Biology, Duke University,
Durham, North Carolina, United States of America, 3 Department of Pathology, Duke University, Durham, North Carolina, United States of America, 4 Department of
Medicine, Duke University, Durham, North Carolina, United States of America, 5 Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North
Carolina, United States of America, 6 Department of Stem Cell Biology and Regenerative Biology, Cleveland Clinic, Cleveland, Ohio, United States of America
Abstract
Background: Malignant gliomas rank among the most lethal cancers. Gliomas display a striking cellular heterogeneity with a
hierarchy of differentiation states. Recent studies support the existence of cancer stem cells in gliomas that are functionally
defined by their capacity for extensive self-renewal and formation of secondary tumors that phenocopy the original tumors.
As the c-Myc oncoprotein has recognized roles in normal stem cell biology, we hypothesized that c-Myc may contribute to
cancer stem cell biology as these cells share characteristics with normal stem cells.
Methodology/Principal Findings: Based on previous methods that we and others have employed, tumor cell populations
were enriched or depleted for cancer stem cells using the stem cell marker CD133 (Prominin-1). We characterized c-Myc
expression in matched tumor cell populations using real time PCR, immunoblotting, immunofluorescence and flow
cytometry. Here we report that c-Myc is highly expressed in gl
您可能关注的文档
- characterization of the p53 response to oncogene-induced senescence表征的p53应对oncogene-induced衰老.pdf
- characterization of the phytochelatin synthase of schistosoma mansoni曼氏裂体吸虫的决定液泡植物螯合肽合成酶的表征.pdf
- characterization of the modular design of the autolysinadhesin aaa from staphylococcus aureus特征的模块化设计autolysinadhesin aaa金黄色葡萄球菌.pdf
- characterization of the molecular determinants of primary hiv-1 vpr proteins impact of the q65r and r77q substitutions on vpr functions表征分子的主要决定因素的hiv - 1蛋白质冲程体积影响q65r和冲程体积r77q替换功能.pdf
- characterization of the pmt gene family in cryptococcus neoformans描述pmt基因家族的新型隐球菌.pdf
- characterization of the primo-vascular system in the abdominal cavity of lung cancer mouse model and its differences from the lymphatic system表征primo-vascular系统的肺癌小鼠的腹腔淋巴系统模型及其差异.pdf
- characterization of the prmt gene family in rice reveals conservation of arginine methylation表征水稻prmt基因家族的揭示了精氨酸甲基化保护.pdf
- characterization of quasispecies of pandemic 2009 influenza a virus (ah1n12009) by de novo sequencing using a next-generation dna sequencer描述2009年流感大流行病毒的准物种(ah1n12009)通过使用下一代dna测序仪从头测序.pdf
- characterization of the psychological, physiological and eeg profile of acute betel quid intoxication in na？ve subjects描述的心理、生理及脑电图的状况在na槟榔急性中毒 ve科目.pdf
- characterization of the resistance of sjlj mice to pneumonia virus of mice, a model for infantile bronchiolitis due to a respiratory syncytial virus描述sjlj小鼠的抗肺炎病毒的老鼠,小儿毛细支气管炎模型由于呼吸道合胞体病毒.pdf
- c-myc regulates self-renewal in bronchoalveolar stem cells原癌基因调节支气管肺泡干细胞的自我更新.pdf
- cnot3 is a modifier of prpf31 mutations in retinitis pigmentosa with incomplete penetrancecnot3修饰符的prpf31基因突变与不完全外显率色素性视网膜炎.pdf
- cns sirt3 expression is altered by reactive oxygen species and in alzheimer’s disease中枢神经系统,sirt3表达式被活性氧和阿尔茨海默氏症.pdf
- cloned, cd117 selected human amniotic fluid stem cells are capable of modulating the immune response克隆,cd117选择人类羊水干细胞能够调节免疫应答.pdf
- co2-driven ocean acidification alters and weakens integrity of the calcareous tubes produced by the serpulid tubeworm, hydroides elegansco2-driven海洋酸化改变和削弱了完整的钙质管由serpulid多毛虫,水螅虫线虫.pdf
- co-administration of a plasmid dna encoding il-15 improves long-term protection of a genetic vaccine against trypanosoma cruzi合并施打一个质粒dna编码il-15提高基因疫苗鲁兹锥体的长期保护.pdf
- coadministration of lopinavirritonavir and rifampicin in hiv and tuberculosis co-infected adults in south africa共同服用lopinavirritonavir和利福平的在南非艾滋病和结核病感染的成年人.pdf
- coagulation changes during presyncope and recovery凝固变化晕厥先兆和恢复.pdf
- coagulation factor x interaction with macrophages through its n-glycans protects it from a rapid clearance凝血因子x与巨噬细胞通过其n-glycans保护它从快速清关.pdf
- coarse-grained prediction of rna loop structures粗粒度预测rna的循环结构.pdf
文档评论（0）