原创力文档combined evaluation of fdg-pet and mri improves detection and differentiation of dementia结合摄影和mri评估改善痴呆的检测和分化.pdfVIP
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combined evaluation of fdg-pet and mri improves detection and differentiation of dementia结合摄影和mri评估改善痴呆的检测和分化
Combined Evaluation of FDG-PET and MRI Improves
Detection and Differentiation of Dementia
1 1 1 3 ¨ 1
Juergen Dukart *, Karsten Mueller , Annette Horstmann , Henryk Barthel , Harald E. Moller , Arno
1,2 3 1,2
Villringer , Osama Sabri , Matthias L. Schroeter
1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Day Clinic of Cognitive Neurology, University of Leipzig, Leipzig, Germany,
3 Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
Abstract
Introduction: Various biomarkers have been reported in recent literature regarding imaging abnormalities in different types
of dementia. These biomarkers have helped to significantly improve early detection and also differentiation of various
dementia syndromes. In this study, we systematically applied whole-brain and region-of-interest (ROI) based support vector
machine classification separately and on combined information from different imaging modalities to improve the detection
and differentiation of different types of dementia.
Methods: Patients with clinically diagnosed Alzheimer’s disease (AD: n = 21), with frontotemporal lobar degeneration (FTLD:
n = 14) and control subjects (n = 13) underwent both [F18]fluorodeoxyglucose positron emission tomography (FDG-PET)
scanning and magnetic resonance imaging (MRI), together with clinical and behavioral assessment. FDG-PET and MRI data
were commonly processed to get a precise overlap of all regions in both modalities. Support vector machine classification
was applied with varying parameters separately for both modalities and to combined information obtained from MR and
FDG-PET images. ROIs were e
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