comparison of sexual behavior and hiv risk between two hiv-1 serodiscordant couple cohorts the chavi 002 study比较两个hiv - 1之间的性行为和艾滋病的风险serodiscordant夫妇军团时002年的研究.pdfVIP

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comparison of sexual behavior and hiv risk between two hiv-1 serodiscordant couple cohorts the chavi 002 study比较两个hiv - 1之间的性行为和艾滋病的风险serodiscordant夫妇军团时002年的研究.pdf

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comparison of sexual behavior and hiv risk between two hiv-1 serodiscordant couple cohorts the chavi 002 study比较两个hiv - 1之间的性行为和艾滋病的风险serodiscordant夫妇军团时002年的研究

Comparison of Sexual Behavior and HIV Risk between Two HIV-1 Serodiscordant Couple Cohorts: The CHAVI 002 Study 1 2 3 3 4 5 Adam J. Ritchie *, Kristin Kuldanek , Zoe Moodie , Z. Maggie Wang , Julie Fox , Rebecca N. Nsubuga , 2 5¤b 5 1 5¤a Kenneth Legg , Esther F. Birabwa , Pontiano Kaleebu , Andrew J. McMichael , Christine Watera , Nilu Goonetilleke1, Sarah Fidler2 1 Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom, 2 HIV Clinical Trials Centre, Imperial College, St Mary’s Hospital, London, United Kingdom, 3 Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 4 Department of HIV, Faculty of Medicine, King’s College, Guy and St Thomas’ Hospital, London, United Kingdom, 5 MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda Abstract Background: The CHAVI002 study was designed to characterize immune responses, particularly HIV-specific T-cell responses, amongst 2 cohorts of HIV-exposed seronegative (HESN) individuals. The absence of a clear definition of HESNs has impaired comparison of research within and between such cohorts. This report describes two distinct HESN cohorts and attempts to quantify HIV exposure using a ‘HIV risk index’ (RI) model. Methods: HIV serodiscordant couples (UK; 24, Uganda; 72) and HIV unexposed seronegative (HUSN) controls (UK; 14, Uganda; 26 couples, 3 individuals) completed sexual behavior questionnaires every 3 months