comprehensive behavioral testing in the r62 mouse model of huntingtons disease shows no benefit from coq10 or minocycline全面的行为测试r62亨廷顿氏舞蹈症的小鼠模型显示没有受益于辅酶q或二甲胺四环素.pdfVIP

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comprehensive behavioral testing in the r62 mouse model of huntingtons disease shows no benefit from coq10 or minocycline全面的行为测试r62亨廷顿氏舞蹈症的小鼠模型显示没有受益于辅酶q或二甲胺四环素.pdf

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comprehensive behavioral testing in the r62 mouse model of huntingtons disease shows no benefit from coq10 or minocycline全面的行为测试r62亨廷顿氏舞蹈症的小鼠模型显示没有受益于辅酶q或二甲胺四环素

Comprehensive Behavioral Testing in the R6/2 Mouse Model of Huntington’s Disease Shows No Benefit from CoQ10 or Minocycline 1 1 1 2 1 Liliana B. Menalled *, Monica Patry , Natalie Ragland , Phillip A. S. Lowden , Jennifer Goodman , Jennie 1 1 3 3 4 5 5 Minnich , Benjamin Zahasky , Larry Park , Janet Leeds , David Howland , Ethan Signer , Allan J. Tobin , Daniela Brunner1,6 1 PsychoGenics Inc., Tarrytown, New York, United States of America, 2 School of Biomedical and Chemical Sciences, Birkbeck College, London, United Kingdom, 3 CHDI Management/CHDI Foundation, Los Angeles, California, United States of America, 4 CHDI Management/CHDI Foundation, Princeton, New Jersey, United States of America, 5 CHDI Management/CHDI Foundation, New York, New York, United States of America, 6 Department of Psychiatry, New York State Psychiatric Institute (NYSPI)/ Columbia University, New York, New York, United States of America Abstract Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington’s disease have produced conflicting results regarding their efficacy in behavioral tests. Using our recently published best practices for husbandry and testing for mouse models of Huntington’s disease, we report that neither coenzyme Q10 nor minocycline had significant beneficial effects on measures of motor function, general health (open field, rotarod, grip strength, rearing-climbing, body weight and survival) in the R6/2 mouse model. The higher doses of minocycline, on the contrary, reduced survival. We were thus unable to confirm the previously reported benefits for these two drugs, and we