原创力文档csf concentrations of camp and cgmp are lower in patients with creutzfeldt-jakob disease but not parkinsons disease and amyotrophic lateral sclerosis脑脊液浓度的阵营和cgmp克雅二氏症患者较低但不是帕金森病和肌萎缩性脊髓侧索硬化症.pdfVIP
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csf concentrations of camp and cgmp are lower in patients with creutzfeldt-jakob disease but not parkinsons disease and amyotrophic lateral sclerosis脑脊液浓度的阵营和cgmp克雅二氏症患者较低但不是帕金森病和肌萎缩性脊髓侧索硬化症
CSF Concentrations of cAMP and cGMP Are Lower in
Patients with Creutzfeldt-Jakob Disease but Not
Parkinson’s Disease and Amyotrophic Lateral Sclerosis
1 2 2 2 3
Patrick Oeckl , Petra Steinacker , Stefan Lehnert , Sarah Jesse , Hans A. Kretzschmar , Albert C.
2 2 1
Ludolph , Markus Otto , Boris Ferger *
1 CNS Diseases Research, Boehringer Ingelheim Pharma GmbH Co. KG, Biberach an der Riss, Germany, 2 Department of Neurology, University of Ulm, Ulm, Germany,
3 Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany
Abstract
Background: The cyclic nucleotides cyclic adenosine-3 9,5 9-monophosphate (cAMP) and cyclic guanosine-39,59-monophos-
phate (cGMP) are important second messengers and are potential biomarkers for Parkinson’s disease (PD), amyotrophic
lateral sclerosis (ALS) and Creutzfeldt-Jakob disease (CJD).
Methodology/Principal Findings: Here, we investigated by liquid chromatography/tandem mass spectrometry (LC-MS/MS)
the cerebrospinal fluid (CSF) concentrations of cAMP and cGMP of 82 patients and evaluated their diagnostic potency as
biomarkers. For comparison with a well-accepted biomarker, we measured tau concentrations in CSF of CJD and control
patients. CJD patients (n = 15) had lower cAMP (270%) and cGMP (255%) concentrations in CSF compared with controls
(n = 11). There was no difference in PD, PD dementia (PDD) and ALS cases. Receiver operating characteristic (ROC) curve
analyses confirmed cAMP and cGMP as valuable diagnostic markers for CJD indicated by the area under the curve (AUC) of
0.86 (cAMP) and 0.85 (cGMP). We calculated a sensitivity of 100% and specificity of 64% for cAMP and a sensitivity of 67%
and specificity of 100
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