decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness决策树算法预测结果诊断和登革热的疾病的早期阶段.pdfVIP

Decision Tree Algorithms Predict the Diagnosis and Outcome of Dengue Fever in the Early Phase of Illness 1. 1. 2 2 3 4 Lukas Tanner , Mark Schreiber , Jenny G. H. Low , Adrian Ong , Thomas Tolfvenstam , Yee Ling Lai , 4 2 5 1 6 Lee Ching Ng , Yee Sin Leo , Le Thi Puong , Subhash G. Vasudevan , Cameron P. Simmons , Martin L. 3 7 Hibberd , Eng Eong Ooi * 1 Novartis Institute for Tropical Diseases, Singapore, 2 Tan Tock Seng Hospital, Singapore, 3 Genome Institute of Singapore, Singapore, 4 National Environment Agency, Singapore, 5 Dong Thap Hospital, Cao Lanh, Dong Thap Province, Vietnam, 6 Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, 7 DSO National Laboratories, Singapore Abstract Background: Dengue is re-emerging throughout the tropical world, causing frequent recurrent epidemics. The initial clinical manifestation of dengue often is confused with other febrile states confounding both clinical management and disease surveillance. Evidence-based triage strategies that identify individuals likely to be in the early stages of dengue illness can direct patient stratification for clinical investigations, management, and virological surveillance. Here we report the identification of algorithms that differentiate dengue from other febrile illnesses in the primary care setting and predict severe disease in adults. Methods and Findings: A total of 1,200 patients presenting in the first 72 hours of acute febrile illness were recruited and followed up for up