原创力文档decreased prevalence of lymphatic filariasis among diabetic subjects associated with a diminished pro-inflammatory cytokine response (cures 83)降低糖尿病患者的淋巴丝虫病流行与减少促炎细胞因子反应(83年治疗).pdfVIP
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decreased prevalence of lymphatic filariasis among diabetic subjects associated with a diminished pro-inflammatory cytokine response (cures 83)降低糖尿病患者的淋巴丝虫病流行与减少促炎细胞因子反应(83年治疗)
Decreased Prevalence of Lymphatic Filariasis among
Diabetic Subjects Associated with a Diminished Pro-
Inflammatory Cytokine Response (CURES 83)
1 1,2 1
Vivekanandhan Aravindhan *, Viswanathan Mohan , Jayagopi Surendar , Maradana Muralidhara
1 3 1 1
Rao , Nathella Pavankumar , Mohan Deepa , Ramanujam Rajagopalan , Vasanthapuram
4 5 3,6
Kumaraswami , Thomas B. Nutman , Subash Babu
1 Madras Diabetes Research Foundation, Chennai, India, 2 Dr. Mohan’s Diabetes Specialties Centre, Chennai, India, 3 National Institutes of Health-International Center for
Excellence in Research, Chennai, India, 4 Tuberculosis Research Center, Chennai, India, 5 Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious
Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, 6 SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America
Abstract
Epidemiological studies have shown an inverse correlation between the incidence of lymphatic filariasis (LF) and the
incidence of allergies and autoimmunity. However, the interrelationship between LF and type-2 diabetes is not known and
hence, a cross sectional study to assess the baseline prevalence and the correlates of sero-positivity of LF among diabetic
subjects was carried out (n = 1416) as part of the CURES study. There was a significant decrease in the prevalence of LF
among diabetic subjects (both newly diagnosed [5.7%] and those under treatment [4.3%]) compared to pre-diabetic
subjects [9.1%] (p = 0.0095) and non-diabetic subjects [10.4%]
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