differential axial requirements for lunatic fringe and hes7 transcription during mouse somitogenesis微分轴向极端分子的要求和在鼠标somitogenesis hes7转录.pdfVIP

Differential Axial Requirements for Lunatic Fringe and Hes7 Transcription during Mouse Somitogenesis Michael Stauber.¤a, Chetana Sachidanandan.¤b, Christina Morgenstern, David Ish-Horowicz* Developmental Genetics Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom Abstract Vertebrate segmentation is regulated by the ‘‘segmentation clock’’, which drives cyclic expression of several genes in the caudal presomitic mesoderm (PSM). One such gene is Lunatic fringe (Lfng), which encodes a modifier of Notch signalling, and which is also express