differential proliferation rhythm of neural progenitor and oligodendrocyte precursor cells in the young adult hippocampus微分扩散节奏的神经祖细胞和少突细胞前体细胞的年轻成年人的海马.pdfVIP

Differential Proliferation Rhythm of Neural Progenitor and Oligodendrocyte Precursor Cells in the Young Adult Hippocampus 1,2 1 3 4 5 Yoko Matsumoto , Yuji Tsunekawa , Tadashi Nomura , Fumikazu Suto , Miho Matsumata , Shigeru 2 1 Tsuchiya , Noriko Osumi * 1 Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Graduate School of Medicine, Tohoku University, Sendai, Japan, 2 Department of Pediatrics, Tohoku University Hospital, Sendai, Japan, 3 Department of Biology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 4 Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan, 5 Department of Developmental Gene Regulation, Brain Science of Institute, RIKEN, Wako, Japan Abstract Oligodendrocyte precursor cells (OPCs) are a unique type of glial cells that function as oligodendrocyte progenitors while constantly proliferating in the normal condition from rodents to humans. However, the functional roles they play in the adult brain are largely unknown. In this study, we focus on the manner of OPC proliferation in the hippocampus of the young adult mice. Here we report that there are oscillatory dynamics in OPC proliferation that differ from neurogenesis in the subgranular zone (SGZ); the former showed S-phase and M-phase peaks in the resting and active periods, respectively, while the latter only exhibited M-phase peak in the active period. There is coincidence between different modes of proliferation and expression of cyclin proteins that are crucial for cell cycle; cyclin D1 is expressed in OPCs, while cyclin D2 is observed in neural stem cells. Similar to ne