dramatic co-activation of wwoxwox1 with creb and nf-κb in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats戏剧性的co-activation wwoxwox1分子和nf-κb延迟损失的小背根神经节神经元在大鼠坐骨神经横断.pdfVIP

Dramatic Co-Activation of WWOX/WOX1 with CREB and NF-kB in Delayed Loss of Small Dorsal Root Ganglion Neurons upon Sciatic Nerve Transection in Rats 1. 2. 3,4. 1,5 5 6 Meng-Yen Li , Feng-Jie Lai , Li-Jin Hsu , Chen-Peng Lo , Ching-Li Cheng , Sing-Ru Lin , Ming-Hui 6 6 6 7 1. 8 Lee , Jean-Yun Chang , Dudekula Subhan , Ming-Shu Tsai , Chun-I Sze , Subbiah Pugazhenthi , Nan- Shan Chang4,5,6,9*, Shur-Tzu Chen1,2 1 Department of Cell Biology Anatomy, National Cheng Kung University Medical College, Tainan, Taiwan, 2 Department of Dermatology, Chi-Mei Medical Center, Tainan, Taiwan, 3 Department of Microbiology Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 4 Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University Medical College, Tainan, Taiwan, 5 Institute of Basic Medical Science, National Cheng Kung University Medical College, Tainan, Taiwan, 6 Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, 7 Putz General Hospital, Department of Health, Executive Yuan, Chiayi, Taiwan, 8 Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, United States of America, 9 Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York, United States of America Abstract Background: Tumor suppressor WOX1 (also named WWOX or FOR) is known to participate in neuronal apoptosis in vivo. Here, we investigated the functional role of WOX1 and transcription facto