dynamics of immune escape during hivsiv infection动力学在hivsiv感染的免疫逃避.pdfVIP

Dynamics of Immune Escape during HIV/SIV Infection Christian L. Althaus*, Rob J. De Boer Theoretical Biology, Utrecht University, The Netherlands Abstract Several studies have shown that cytotoxic T lymphocytes (CTLs) play an important role in controlling HIV/SIV infection. Notably, the observation of escape mutants suggests a selective pressure induced by the CTL response. However, it remains difficult to assess the definite role of the cellular immune response. We devise a computational model of HIV/SIV infection having a broad cellular immune