early life stress differentially modulates distinct forms of brain plasticity in young and adult mice早期生活应激不同调节不同形式的年轻成年老鼠的大脑可塑性.pdfVIP

Early Life Stress Differentially Modulates Distinct Forms of Brain Plasticity in Young and Adult Mice 1. 1. 2 1 2 1 Inga Herpfer , Henning Hezel , Wilfried Reichardt , Kristin Clark , Julia Geiger , Claus M. Gross , 1 1 1 1 1 Andrea Heyer , Valentin Neagu , Harsharan Bhatia , Hasan C. Atas , Bernd L. Fiebich , 3 4 5 1 Josef Bischofberger , Carola A. Haas , Klaus Lieb , Claus Normann * 1 Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany, 2 Department of Radiology, Medical Physics, University of Freiburg Medical School, Freiburg, Germany, 3 Department of Biomedicine, University of Basel, Basel, Switzerland, 4 Experimental Epilepsy Group, Neurocenter, University of Freiburg Medical School, Freiburg, Germany, 5 Department of Psychiatry, University Medical Center Mainz, Mainz, Germany Abstract Background: Early life trauma is an important risk factor for many psychiatric and somatic disorders in adulthood. As a growing body of evidence suggests that brain plasticity is disturbed in affective disorders, we examined the short-term and remote effects of early life stress on different forms of brain plasticity. Methodology/Principal Findings: Mice were subjected to early deprivation by individually separating pups from their dam in the first two weeks after birth. Distinct forms of brain plasticity were assessed in the hippocampus by longitudinal MR volumetry, immunohistochemistry of neurogenes