effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression a randomized trial慢性酞与安慰剂对人格特质的影响在健康抑郁症患者的一级亲属随机试验.pdfVIP

Effect of Chronic Escitalopram versus Placebo on Personality Traits in Healthy First-Degree Relatives of Patients with Depression: A Randomized Trial 1,2,4 1 2 3 3 3 Ulla Knorr *, Maj Vinberg , Erik Lykke Mortensen , Per Winkel , Christian Gluud , Jørn Wetterslev , Ulrik Gether4, Lars Vedel Kessing1 1 Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark, 2 Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, University Hospital Copenhagen, Copenhagen, Denmark, 3 Department of Health Psychology, University of Copenhagen, Copenhagen, Denmark, 4 Department of Neuroscience and Pharmacology, Centre for Pharmacogenomics, University of Copenhagen, Copenhagen, Denmark Abstract Introduction: The serotonergic neurotransmitter system is closely linked to depression and personality traits. It is not known if selective serotonin reuptake inhibitors (SSRI) have an effect on neuroticism that is independent of their effect on depression. Healthy individuals with a genetic liability for depression represent a group of particular interest when investigating if intervention with SSRIs affects personality. The present trial is the first to test the hypothesis that escitalopram may reduce neuroticism in healthy first-degree relatives of patients with major depressive disorder (MD). Methods: The trial used a randomized, blinded, placebo-controlled parallel-group design. We examined the effect of four weeks escitalopram 10 mg daily versus matching placebo on personality in 80 people who had a biological parent or sibling with a history of MD. The outcome measure on personality trait