原创力文档first report of sylvatic denv-2-associated dengue hemorrhagic fever in west africa第一次报告的森林型denv-2-associated登革出血热在西非.pdfVIP
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first report of sylvatic denv-2-associated dengue hemorrhagic fever in west africa第一次报告的森林型denv-2-associated登革出血热在西非
First Report of Sylvatic DENV-2-Associated Dengue
Hemorrhagic Fever in West Africa
1 . 2. ´ 3 ´ 1 2
Leticia Franco * , Gustavo Palacios , Jose Antonio Martinez , Ana Vazquez , Nazir Savji , Fernando De
1 ´ 1 ´ 4 2 1
Ory , Marıa Paz Sanchez-Seco , Dolores Martın , W. Ian Lipkin , Antonio Tenorio
1 National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain, 2 Center for Infection and Immunity, Mailman School of Public Health,
´
Columbia University, New York, New York, United States of America, 3 Hospital Infanta Cristina, Parla, Madrid, Spain, 4 Laboratorio Br Salud, San Sebastian de los Reyes,
Madrid, Spain
Abstract
Dengue virus (DENV) circulates in human and sylvatic cycles. Sylvatic strains are both ecologically and evolutionarily distinct
from endemic viruses. Although sylvatic dengue cycles occur in West African countries and Malaysia, only a few cases of
mild human disease caused by sylvatic strains and one single case of dengue hemorrhagic fever in Malaysia have been
reported. Here we report a case of dengue hemorrhagic fever (DHF) with thrombocytopenia (13000/ml), a raised hematocrit
(32% above baseline) and mucosal bleeding in a 27-year-old male returning to Spain in November 2009 after visiting his
home country Guinea Bissau. Sylvatic DENV-2 West African lineage was isolated from blood and sera. This is the first case of
DHF associa
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