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first trial of male circumcision against hiv男性包皮环切术对抗hiv的第一次审判
Open access, freely available online
Synopses of Research Articles
Casting Doubt on the Role of Mitochondria in Tumorigenesis
DOI: 10.1371/journal.pmed.0020373
Mitochondrial DNA (mtDNA) has been intensively studied over
the past two decades, and point mutations, more commonly
known as deletions, of this DNA are known to be involved in
several syndromes. Unlike nuclear DNA, with 46 chromosomes,
half from each parent, mtDNA is just one piece of genome of
which there are many copies, but all copies come only from the
mother. Mitochondrial disease syndromes, such as MELAS, have
a range of different clinical manifestations depending on how
many copies of the abnormal mtDNA are present in affected
cells.
There are several international resources of mtDNA sequences.
From these sequences, it has been possible to show that different
population groups have different patterns of substitutions in the
mtDNA—so-called haplogroups; this information has been used,
for example, in the investigation of the origin and migration
patterns of human populations, and some investigators have DOI: 10.1371/journal.pmed.0020373.g001
even suggested that it could be used to trace back to earliest The Role of Mitochondria in Tumorigenesis is not yet clear
human history the founding mothers of humanity.
More recently, however, attention has turned to the question
of whether mtDNA is involved in tumor formation. However, the result of such sequencing “disasters” is that fl awed results
are not fi ltered out from the clinical literature, which makes the
deciding whether mutations are harmful or innocuous has
been diffi cult. One concern is that isolation of mtDNA from any task of interpreting
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